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KMID : 0984720080400020110
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Infection and Chemotherapy
2008 Volume.40 No. 2 p.110 ~ p.115
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Invasive Aspergillosis of the Paranasal Sinuses Invading Skull Base: Successful Treatment with Voriconazole
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Eun Chai-Ryoung
Heo Jung-Yeon
Noh Ji-Yun
Youn Young-Kyoung
Lee Hyun-Joo
Shin Bong-Kyung
Lee Jae-Gap
Song Jun-Young
Cheong Hee-Jin
Kim Woo-Joo
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Abstract
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Skull base-invading, invasive aspergillosis is rare, but it is a potentially life-threatening disease. Nevertheless, the standard method and the optimal duration of treatment are not known yet. A 52-year-old female diabetic patient complained of ophthalmalgia and decreased visual acuity. MRI and CT scan revealed an enhancing mass in the right orbital fissure and showed an infiltrating process in the skull base around the right orbit apex and paranasal sinuses. The histological investigation revealed invasive aspergillosis of paranasal sinuses and the skull base. Clinical improvement occurred after marsupialization and post-operative systemic antifungal therapy with voriconazole for 14 weeks. We suggest that voriconazole treatment could show effective results for invasive aspergillosis of skull base and paranasal sinuses.
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KEYWORD
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Invasive aspergillosis, Skull base, Voriconazole
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